August 27, 2015

$2.8 million NIH grant advances hearing loss research

School of Medicine researcher Kathleen Campbell, professor in the Department of Surgery, has secured a five-year grant from the National Institutes of Health (NIH) to advance her decades of research in hearing loss prevention and treatment. The total budget for the project is $2.8 million.

This grant will determine the optimal dosing level of D-methionine (D-met), a compound that has been shown to prevent hearing loss. D-met is an amino acid that has been found to protect against noise-induced hearing loss and ototoxicity, or damage to the ear caused by some antibiotics and platinum-based chemotherapy agents, such as cisplatin.

“With the help of our current Department of Defense lab funding, we have found that the optimal D-met protection is dose-sensitive, with higher or lower dosing reducing efficacy,” Campbell said. “Thus, with this grant, we will determine the optimal dosing level as well as when that dose will be most effective.” If successful, the clinical use of D-met otoprotection will move one step closer to FDA approval.

According to Campbell, D-met can provide both “rescue” and protective functions in preventing permanent noise-induced hearing loss.

“We've found that D-met can provide this ‘rescue’ protection very effectively if first initiated up to 24 hours after noise exposure and with lesser protection up to 36 hours after,” Campbell said. “Rescue therapy would be of great clinical use after unexpected noise exposures, such as car airbag deployment, high sound level concerts, fireworks, emergency work or battlefield weaponry.”

Similarly, Campbell has discovered D-met's ability to prevent hearing loss if given before noise exposure.

In addition to determining the optimal dose of D-met, Campbell will examine how specific biomarkers impact the dose's effectiveness.

Campbell's research, which has been previously funded by the Department of Defense, Veterans Administration, Illinois Department of Health and the National Institutes of Health, has secured more than $11 million in funding since she joined the SIU School of Medicine in 1989. Named a 2014 Outstanding Scholar, Campbell has been featured in numerous well-known publications, including The Wall Street Journal, Popular Science and The New York Times.