Accomplishments - May, 2026

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Matthew J. Young, associate professor of biochemistry and molecular biology; researcher Carolyn Young; and graduate students Md. Mostafijur Rahman and Pabitra Khadka, all from the SIU School of Medicine-Carbondale Department of Biomedical Sciences, collaborated with partners at the Children’s Hospital of Philadelphia to co-author a paper titled ”High-concentration MEHP triggers mtDNA depletion in undifferentiated HepaRG and C2C12 cultures and disrupts mitochondrial homeostasis in both HepaRG culture states.” The study was recently published in the journal “Toxicological Sciences.” The authors found that the phthalate contaminant metabolite, MEHP, causes cell-state-dependent toxicity, with early effects on cell density occurring at lower exposures than those required to cause mtDNA depletion, offering important insights for risk assessment.

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